Veterans with severe obstructive sleep apnea (OSA) experienced less improvement in PTSD symptoms when treated with esketamine.
Veterans with severe obstructive sleep apnea (OSA) experienced less improvement in PTSD symptoms when treated with esketamine.
High obstructive sleep apnea severity at baseline may interfere with the effectiveness of esketamine for PTSD.
High obstructive sleep apnea severity at baseline may interfere with the effectiveness of esketamine for PTSD.
Screening and treating obstructive sleep apnea before administering esketamine could improve clinical outcomes.
Screening and treating obstructive sleep apnea before administering esketamine could improve clinical outcomes.
A study analyzed 24 veterans with PTSD who received intranasal esketamine treatment.
A study analyzed 24 veterans with PTSD who received intranasal esketamine treatment.
Changes in PTSD symptoms were assessed using the PTSD Checklist for DSM-5 (PCL-5) scores.
Changes in PTSD symptoms were assessed using the PTSD Checklist for DSM-5 (PCL-5) scores.
PCL-5 scores significantly decreased with each esketamine dose, indicating symptom improvement.
PCL-5 scores significantly decreased with each esketamine dose, indicating symptom improvement.
Patients with higher baseline obstructive sleep apnea severity showed fewer changes in PCL-5 scores over the course of esketamine treatment.
Patients with higher baseline obstructive sleep apnea severity showed fewer changes in PCL-5 scores over the course of esketamine treatment.
The relationship between obstructive sleep apnea severity, esketamine, and PTSD symptoms requires further research.
The relationship between obstructive sleep apnea severity, esketamine, and PTSD symptoms requires further research.
Future studies should explore the effects of continuous positive airway pressure (CPAP) and different OSA endotypes on esketamine's impact.
Future studies should explore the effects of continuous positive airway pressure (CPAP) and different OSA endotypes on esketamine's impact.
Understanding the effects of esketamine on upper airway collapsibility is also important in the context of OSA severity and PTSD treatment.
Understanding the effects of esketamine on upper airway collapsibility is also important in the context of OSA severity and PTSD treatment.